Personal Profile
Dr Peng-Yuan Wang, Distinguished Principal Investigator of Oujiang Laboratory. He has received several prestigious awards, including the ARC DECRA Fellowship, the VESKI Fellowship, the China Overseas High-level Talents, and the Zhejiang Overseas High-level Talents. He was a PI at Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), and the Director of Shenzhen Key Laboratory of Biomimetic Materials and Cellular Immune Regulation. He has received many awards, such as Vice-Chancellor's Award of Swinburne University, and the representative of China-Australia young scientists.
Dr Wang’s group has developed a variety of bioengineering tools and methods to study the regulation of unique biomechanotransduction signaling. Mammalian cells attach to the extracellular matrix (ECM), where the surfaces control cell adhesion, cytoskeleton, and nucleus. Then, these changes regulate cell behavior, transcriptome profile, and epigenetic state. The research has important significance and potential application in organ development and materiobiology, and the outcomes play a guiding role in designing new biomaterials and cell therapy approaches.
Dr Wang’s group has published more than 100 SCI papers, with over 70 being the first/corresponding authors, including Adv Funct Mater (2), ACS Nano (2), Small (3), Mol Ther (2), ACS Appl Mater Inter (10), Acta Biomater (5), etc. He also holds 8 granted invention patents.
atents.
Representative Works
1.P Du, X Tao, J Harati, Y Shi, L Xiao, X Li, H Pan, PY Wang* “Human platelet lysate enhances small lipid droplet accumulation of human MSCs through MAPK phosphorylation” Stem Cell Research & Therapy 2024, 15 (1), 473
2.J Mei, XY Jiang, HX Tian, DC Rong, JN Song, L Wang, YS Chen, RCB Wong, CX Guo, LS Wang, LY Wang, PY Wang*, JY Yin* “Anoikis in cell fate, physiopathology, and therapeutic interventions” MedComm, 2024, 5 (10), e718
3.J Harati, P Du, M Galluzzi, X Li, J Lin, H Pan, PY Wang* “Tailored Physicochemical Cues Direct Human Mesenchymal Stem Cell Differentiation through Epigenetic Regulation Using Colloidal Self-Assembled Patterns” ACS Applied Materials & Interfaces 2024, 35912
4.JN Song, K Liu, J Mei, L Wang, J Lin, P Du, YC Liu, Y Wan, RCB Wong, JY Yin, PY Wang*. “Defined Surface Physicochemical Cues Inhibit M1 Polarization of Human Macrophages Using Colloidal Self-Assembled Patterns”ACS Applied Materials & Interfaces 2023, 35832
5.J Harati, K Liu, H Shahsavarani, P Du, M Galluzzi, K Deng, J Mei, HY Chen, S Bonakdar, B Aflatoonian, G Hou, Y Zhu, H Pan, RB Wong, M Ali Shokrgozar, W Song, PY Wang* “Defined Physicochemical Cues Steering Direct Neuronal Reprogramming on Colloidal Self-Assembled Patterns (cSAPs)”ACS Nano 2022, 1054
6.P Du, X Tao, K Liu, J Lin, Y Shi, K Park, HY Chen, CP Lin, J Chang, RCB Wong, H Pan, PY Wang* “Human platelet lysate (hPL) alters the lineage commitment and paracrine functions of human mesenchymal stem cells via mitochondrial metabolism” Applied Materials Today 2022, 101264
7.Y Shi, J Lin, X Tao, J Qu, S Liao, M Li, K Deng, P Du, K Liu, H Thissen, L Li, P Kingshott , PY Wang* “Harnessing Colloidal Self-Assembled Patterns (cSAPs) to Regulate Bacterial and Human Stem Cell Response at Biointerfaces In Vitro and In Vivo” ACS Applied Materials & Interfaces 2021, 20982
8.K Deng, P Du, K Liu, X Tao, J Harati, JW Jhang, J Kim, PY Wang* “Programming Colloidal Self-Assembled Patterns (cSAPs) into Thermo-Responsible Hybrid Surfaces for Controlling Human Stem Cells and Macrophages” ACS Applied Materials & Interfaces 2021, 18563
9.R Chang, Q Yan, P Kingshott, WB Tsai, PY Wang* “Harnessing the perinuclear actin cap (pnAC) to influence nanocarrier trafficking and gene transfection efficiency in skeletal myoblasts on nanopillars” Acta Biomater, 2020, 221.
Team Introduction
The team, led by Dr. Wang Peng-Yuan as the Principal Leader, comprises 2 associate researchers, 2 postdoctoral fellows, 4 research assistants, and 12 students. With an average age lower than 30, the team is youthful, dynamic, and characterized by vitality and creativity.
Over the past decade, our team has been dedicated to the field of mechanobiology and materiobiology, accumulating rich achievements and experience in areas such as bioengineering, directed differentiation of stem cells, and cell reprogramming. To date, we have published over 100 academic papers in renowned international journals, including sub-journals of Nature and Cell.
Since 2018, Dr. Wang has successfully secured funding for 2 national key R&D programs (MOST), 1 national natural science foundation of China (NSFC) projects, 2 international cooperation projects with the Chinese Academy of Sciences, 1 provincial-level international cooperation project, and 1 key laboratory project at the municipal level, totaling over 20 million RMB in approved funding.
Looking ahead, the team will continue to delve into the fundamental research and industrial applications of bioengineering materials in the field of stem cells. Our focus is on addressing key scientific and technological challenges in the clinical application of biomaterials and cell therapy, unraveling underlying scientific questions, and striving to produce high-quality cells. Additionally, we aim to develop bioengineering materials that are irreplaceable, pioneering the future of biomaterials and cell technology.
Recruitment Needs
I. Associate Researchers/Postdoctoral Fellows (1-2 positions)
1. Discipline: Biology, Materials, Chemistry.
2. First authorship in more than 2 SCI papers.
3. Experience in project proposal submission.
4.Proficiency in English (priority given to applicants with English proficiency certificates).
5. Positive character, diligent and proactive, optimistic and focused on future goals.
6. Additional bonus materials.
II. Compensation and Benefits
1.Associate Researchers: Annual salary > 200,000 RMB + year-end research performance bonus, talent housing provided.
2.Postdoctoral Fellow A: Annual salary > 350,000 RMB + year-end research performance bonus, talent housing provided.
3.Postdoctoral Fellow B: Annual salary > 300,000 RMB + year-end research performance bonus, talent housing provided.
4.Research Assistants: Annual salary > 150,000 RMB, talent housing provided, enjoying unit-provided benefits.
5.All positions follow the salary standards of Oujiang Laboratory and comply with relevant policies of Zhejiang Province/Wenzhou City.
6.Depending on experience and title, candidates may be eligible for employment under Wenzhou City's public institution system, receive relocation subsidies, housing subsidies, transitional housing, etc. Under permissible conditions, joint training with universities in Australia, California (USA), Shanghai, Shenzhen, and other locations is possible.
III. Application process
1.Interested candidates are invited to submit a detailed personal resume (in both Chinese and English) via email, including a list of representative academic achievements such as papers, patents, conference presentations, and details of projects hosted/participated in.
2.Please use the following email format for submission: Send an email to py.wang@ojlab.ac.cn with the subject line indicating "Position + Your Name." The personal resume will be rigorously screened, and interviews will be promptly arranged (via Tencent Meeting) for qualified candidates. Those who do not pass the screening will not receive further notification.
Personal information will be treated with strict confidentiality. Highlight your outstanding academic achievements and qualities in your application.
