Researcher/Independent PI of Oujiang Laboratory, born in 1990, is a Distinguished Researcher of the First Hospital of Wenzhou Medical University, selected for the 2023 National High-level Young Talent Program. D. graduated from Radboud University (Netherlands) in 2018, supervised by Wilhelm Huck (Member of the Royal Netherlands Academy of Sciences, Member of the European Academy of Sciences); before returning to China, he worked successively at the University of Cambridge and Caltech Neuroscience Institute Magdalena Zernicka-Goetz (Fellow of the British Academy of Medical Sciences) Before returning to China, Magdalena Zernicka-Goetz (Fellow of the British Academy of Medical Sciences) worked as a postdoctoral researcher at Cambridge University and Caltech Neuroscience Institute. In recent years, he has constructed biologically active tissue and organ and early development models with cell mechanics as the core and utilized multidisciplinary cross-cutting techniques, as well as investigated the mechanisms of disease development and repair. He has carried out a series of original and highly original researches in the direction of cell mechanics signal transduction and precision construction of life-like organisms. He has published more than 10 papers in Nature Cell Biology, Nature Communication, Advanced Science, Biomaterials, etc., and has been invited to write reviews in Current Opinion, Annual Review, etc., as the first or corresponding author. He has been invited to write reviews in Current Opinion, Annual Review and other journals as the first or corresponding author. He has been awarded the National Outstanding Self-financed International Student Scholarship, the full PhD scholarship of Radboud University, the Netherlands, and the Distinguished Reviewer of the British Biophysical Society. His current main research interests are biomechanics and brain diseases.

1、Biomechanics and mechanical signal transduction

2、Mechanisms of brain diseases

3、Mechanics-guided precise construction and application of class system

4、Stem cell fate regulation mechanism and application

我们仿生再造与生物力学（BMRBM）课题组位于浙江省温州市，依托单位为瓯江实验室，课题组主要研究梯队包括PI、副研究员、助理研究员、博士后和研究生，拥有良好的学术氛围、科学基础和临床资源。我们以细胞、组织器官、小鼠为主要研究模型，重点开展以下研究：

（1）针对生物力学信号在组织器官发育和疾病发生发展中的重要作用，研究并揭示力学因子在脑发育及脑疾病发生发展过程中的独特作用以及与其它因素的协同作用。

（2）利用交叉学科技术方法，精准构建基于干细胞的类器官和类胚胎，重点研究工程化组织器官构建的生物力学和结构基础，为合成生物学、基础科学与医学应用提供新模型。

（3）以细胞、类器官和小鼠为模型，研究脑类疾病发病机制，探索不同药物在修复这些疾病方面的应用。并尝试利用类脑器官和干细胞移植等手段，修复或预防脑类疾病的发生发展。

（4）整合生物材料设计，细胞工程及三维生物制造等手段，以再生医学为核心，调控细胞和组织器官命运，并尝试开发出有效的临床治疗手段，解决组织再生等重大医学问题。

课题组长期招聘具有细胞生物学和分子生物学背景的研究人员，我们热诚地欢迎对脑科学、神经科学、发育生物学、干细胞生物学、生物力学、类器官构建、生物信息学、生物工程学等领域感兴趣的硕士研究生、博士研究生、博士后和专业技术人员加入我们！

更多信息请参考我们课题组网站：https://www.x-mol.com/groups/baomin