Ouyang Zhongcan


Director of High-end Medical Device Cluster
Academician of Chinese Academy of Sciences
Academic Leader of Oujiang Laboratory


Personal Profile

Academician of the Chinese Academy of Sciences (CAS), he received his B.S. (1968), M.S. (1981) and Ph.D. (1984) degrees from Tsinghua University, and was the first postdoctoral fellow in China. 1985, he was awarded the Humboldt Scholarship to go to Freie Universität Berlin and collaborate with Prof. W. Helfrich, who is the famous inventor of the LCD and the creator of the theory of liquid crystal biofilm. After returning to China, he became an associate researcher and a researcher at the Institute of Theoretical Physics, Chinese Academy of Sciences (IUPAC), and served as the director of IUPAC from 1998 to 2007. His main academic contributions are the theory of biofilm elasticity, etc. He is the pioneer of physical biology in China, and the planner and promoter of China's liquid crystal panel industry. Recently, he has been focusing on the cross research between physical biology and life science, and expects to realize the breakthrough of the basic principle and technology of “ultrasound brain imaging” in Oujiang Laboratory.

Research Direction
Liquid crystals, biofilm theory;
DNA biomolecule elastic properties and protein folding mechanism;
Cross research of physics, chemistry and biology.
Participate Project
Academician Zhongchan Ouyang has made outstanding contributions in several important areas of soft condensed matter physics and statistical physics. He has been invited to present at several international conferences, such as the 21st IUPAP International Conference on Statistical Physics and Biomembrane Days 2019. He has published more than 100 papers in international renowned journals, one monograph in English (supplemented with Chinese version), and one scientific pamphlet, which is well received by readers. The main scientific achievements are:
1. derived the shape equation of a liquid membrane vesicle and obtained an analytical solution with exactly the same shape as that of an erythrocyte biconcave, solving a long-standing problem in physiology;
2. predicted a cyclic solution to the equation of shape of an erythrocyte biconcave, in which the two generating circle radii r and R's must satisfy the conditions image.png or 0, which was soon confirmed experimentally;
3. proposed a theory (generalized in 1998) to describe the helical structure of chiral bilayers, which agrees well with experimental observations.
4. proposed a theory for the formation of Smectic-A LC (SmA) domains, which solved the problem of the variation of the curvature elastic energy of SmA and revealed the formation mechanism of focal cone domains (FCD). By analogy with the SmA theory, the spiral phenomenon of multilayer carbon nanotubes was successfully explained.
5. proposed the statistical elasticity of double-stranded DNA molecules and the transition mechanism of hairpin-helix of single-stranded DNA/RNA;
6. in collaboration with an experimental group in the U.S.A., calculated the elastic modulus of wafl DNA (the response element of p53 regulatory protein), and found that it is only 1/3 of the elastic modulus of random sequence DNA. this result revealed the mechanism of tumor suppressor activity of p53;
7. proposed the opening and closing mechanism of magnetically controlled nanobubble valves.
Representative Works
1.Y. G. Shu and Z. C. Ou-Yang, Manipulated deformation of lipid bilayer vesicles in magnetic fields, Liquid Crystals, 2023, Doi:10.1080/02678292.2022.2154866.
2.M. Iwamoto and Z. C. Ou-Yang, Shape Deformation and Circle Instability in Two-Dimensional Lipid Domains by Dipolar Force: A Shape- and Size-Dependent Line Tension Model, Phys. Rev. Lett., 93(2004),206101.
3.Z. C. Ou-Yang, Z. B. Su and C. L. Wang, Coil Formation in Multishell Carbon Nanotubes: Competition between Curvature Elasticity and Interlayer Adhesion, Phys. Rev. Lett., 78(1997)4055-4058.
4.Z. C. Ou-Yang, Anchor ring-vesicle membranes, Phys. Rev. A., 41(1990)4517-4520.
5.Z. C. Ou-Yang and W. Helfrich, Instability and Deformation of a Spherical Vesicle by Pressure, Phys. Rev. Lett., 59(1987)2486-2488.
Personal Honor
1. The First Overseas Chinese Physics Society Award for Outstanding Achievement in Asian Physics, 1993;
2. The First Chinese Postdoctoral Fellowship “Guo's Prize”, 1994.
3. 1995, First Prize in Natural Science, Chinese Academy of Sciences.
4. 1996, recognized by the Ministry of Personnel as a young and middle-aged expert with outstanding contributions.
5. 1997, elected as Academician of the Chinese Academy of Sciences.
6. 1999 Awarded the Zhou Peiyuan Prize
7. 1999 Awarded the Second Prize of National Natural Science.
8. Elected Member of the Academy of Sciences for the Developing World in 2003.
9. 2004 Awarded the Ho Leung Ho Lee Prize for Scientific and Technological Progress.
10. 2015 Elected Foreign Member of the Japanese Society of Applied Physics.
Team Introduction
Recruitment Needs

official account

Contact Address:中国浙江省温州市龙湾区永中街道金石路999号

Zip Code:325000

Email:zh@ojlab.ac.cn

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