Lu Fan


One of the renowned scholars and leaders in the field of ophthalmic optics
Professor / Doctoral Supervisor / Postdoctoral Supervisor
Dual-appointed PI of Oujiang Laboratory
Director of National Clinical Medical Research Center, Affiliated Optometry Hospital of Wenzhou Medical University, China
E-mail: lufan62@mail.eye.ac.cn


Personal Profile

Professor Lu Fan is the first expert to earn an Optometry Doctor (OD) degree from the New England College of Optometry in the United States and return to China. She is a leading scholar and pioneer in the optometry field in China, having established a comprehensive system of optometric medical education and clinical disciplines with her team. This system has significantly influenced optometry education and the medical field both in China and internationally. Professor Lu has spearheaded more than twenty major national research projects, including those funded by the National Key R&D Program of China, the National Natural Science Foundation of China, the National Key Technology R&D Program of the Ministry of Science and Technology of China.She has also been involved in major scientific instrument projects, Sino-US cooperative projects of the Ministry of Science and Technology of China, and the Ministry of Education's 111 Plan. She has authored over 200 papers , published in prestigious journals such as PNAS, Nature Communications, Mucosal Immunology, Allergy, IOVS, and Ophthalmology. Her contribution to science and education have been recognized with several awards, including the Second Prize of the State Science and Technology Advancement Award, the First Prize of Science and Technology Advancement Award of Zhejiang Province, and the Second Prize of National Teaching Achievement Award. In 2010, she was honored with a Doctor of Vision Science by the New England College of Optometry, and in 2020 received the Distinguished Alumni Award from the same institution.


Research Direction
1.Basic and Clinical Research on Myopia Correction:
2.Eye Imaging Technology and the Diagnosis and Treatment of Ocular Diseases:
3.Visual function Research Related to Binocular Functions, Regulation, Refractive Surgery, Low Vision Rehabilitation, Optical Correction, and Contact Lens:
Participate Project
Representative Works
[1] Yuan Y, Shao Y, Tao A, Shen M, Wang J, Shi G, Chen Q, Zhu D, Lian Y, Qu J, Zhang Y, Lu F. Ocular anterior segment biometry and high-order wavefront aberrations during accommodation. Invest Ophthalmol Vis Sci. 2013; 54(10): 7028-37. doi: 10.1167/iovs.13-11893.
[2] Hu L, Wang Q, Yu P, Yu Y, Zhang D, He JC, Lu F. The influence of intraocular pressure on wavefront aberrations in patients undergoing laser-assisted in situ keratomileusis. Invest Ophthalmol Vis Sci. 2013; 54(8): 5527-34. doi: 10.1167/iovs.12-11349. PMID: 23778879.
[3] Tao A, Chen Z, Shao Y, Wang J, Zhao Y, Lu P, Lu F. Phacoemulsification induced transient swelling of corneal Descemet's Endothelium Complex imaged with ultra-high resolution optical coherence tomography. PLoS One. 2013; 8(11): e80986. doi: 10.1371/journal.pone.0080986.
[4] Liu X, Shen M, Yuan Y, Huang S, Zhu D, Ma Q, Ye X, Lu F. Macular Thickness Profiles of Intraretinal Layers in Myopia Evaluated by Ultrahigh-Resolution Optical Coherence Tomography. Am J Ophthalmol. 2015; 160(1): 53-61.e2. doi: 10.1016/j.ajo.2015.03.012.
[5] Xu Z, Peng M, Jiang J, Yang C, Zhu W, Lu F, Shen M. Reliability of Pentacam HR Thickness Maps of the Entire Cornea in Normal, Post-Laser In Situ Keratomileusis, and Keratoconus Eyes. Am J Ophthalmol. 2016; 162: 74-82.e1. doi: 10.1016/j.ajo.2015.11.008.
[6] Yang J, Jin ZB, Chen J, Huang XF, Li XM, Liang YB, Mao JY, Chen X, Zheng Z, Bakshi A, Zheng DD, Zheng MQ, Wray NR, Visscher PM, Lu F, Qu J. Genetic signatures of high-altitude adaptation in Tibetans. Proc Natl Acad Sci U S A. 2017; 114(16): 4189-4194. doi: 10.1073/pnas.1617042114.
[7] Jin ZB, Wu J, Huang XF, Feng CY, Cai XB, Mao JY, Xiang L, Wu KC, Xiao X, Kloss BA, Li Z, Liu Z, Huang S, Shen M, Cheng FF, Cheng XW, Zheng ZL, Chen X, Zhuang W, Zhang Q, Young TL, Xie T, Lu F, Qu J. Trio-based exome sequencing arrests de novo mutations in early-onset high myopia. Proc Natl Acad Sci U S A. 2017; 114(16): 4219-4224. doi: 10.1073/pnas.1615970114.
[8] Jiang S, Chen Z, Bi H, Xia R, Shen T, Zhou L, Jiang J, Zhang B, Lu F. Elucidation of the more myopic eye in anisometropia: the interplay of laterality, ocular dominance, and anisometropic magnitude. Sci Rep. 2019; 9(1): 9598. doi: 10.1038/s41598-019-45996-1.
[9] Gao H, Zhao S, Zheng G, Wang X, Zhao R, Pan Z, Li H, Lu F, Shen M. Using a dual-stream attention neural network to characterize mild cognitive impairment based on retinal images. Comput Biol Med. 2023; 166: 107411. doi: 10.1016/j.compbiomed.2023.
[10] Li C, Zhu X, Yang K, Ju Y, Shi K, Xiao Y, Su B, Lu F, Cui L, Li M. Relationship of retinal capillary plexus and ganglion cell complex with mild cognitive impairment and dementia. Eye (Lond). 2023; 37(18): 3743-3750. doi: 10.1038/s41433-023-02592-y.
[11] Li K, Gong Q, Lu B, Huang K, Tong Y, Mutsvene TE, Lin M, Xu Z, Lu F, Li X, Hu L. Anti-inflammatory and antioxidative effects of gallic acid on experimental dry eye: in vitro and in vivo studies. Eye Vis (Lond). 2023; 10(1): 17. doi: 10.1186/s40662-023-00334-5.
[12] Zhou Y, Lin G, Yu X, Cao Y, Cheng H, Shi C, Jiang J, Gao H, Lu F, Shen M. Deep learning segmentation of the tear fluid reservoir under the sclera lens in optical coherence tomography images. Biomed Opt Express. 2023; 14(5): 1848-1861. doi: 10.1364/BOE.480247.
[13] Su B, Bao Z, Guo Y, Zheng H, Zhou J, Lu F, Jiang J. Changes in Shape Discrimination Sensitivity Under Glare Conditions After Orthokeratology in Myopic Children: A Prospective Study. Invest Ophthalmol Vis Sci. 2023; 64(1): 6. doi: 10.1167/iovs.64.1.6.
Personal Honor
Team Introduction
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