1990.09—1994.08华东师范大学获化学专业学士学位

2002.09—2005.01华东师范大学获生物化学专业硕士学位

2009.03—2014.01南京理工大学获生化药学博士学位

1994.08—至今温州医科大学教师

(其间：2015.03—2016.09哈佛医学院/麻省总院神经保护研究中心博士后）

（1）成纤维细胞生长因子及其受体在脑内的分布及其对中枢神经系统疾病的治疗作用。

（2）成纤维细胞生长因子治疗中枢神经系统疾病脑靶向递送系统的开发。

（1）细胞外囊泡靶向递送aFGF对2型糖尿病合并缺血性脑卒中神经血管再生及功能修复研究，国家自然科学基金面上项目，49万元，2024.01-2027.12，主持

（2）可注射温敏型肝素泊洛沙姆-FGF20水凝胶对缺血性脑卒中神经血管单元修复与再生作用研究，国家自然科学基金面上项目，55万元，2022.01-2025.12，主持

（3）脑源性FGF20靶标脑血管对创伤性脑损伤的保护和修复作用及其机制研究，国家自然科学基金面上项目，55万元，2020.01-2023.12，主持

（4）FGF21调控小胶质细胞介导的神经免疫炎症促进2型糖尿病缺血性脑卒中后神经功能的修复，国家自然科学基金面上项目，2018.01-2021.12，54万元，主持

（5）医药卫生省部共建重点项目（WKJ-ZJ-2130），温敏型肝素泊洛沙姆-FGF20水凝胶对缺血性脑卒中中的治疗作用研究，15万，2020.01-2023.12，主持

（6）温州市重大科技创新攻关医疗卫生项目（ZY2019001），治疗糖尿病合并缺血性脑卒中一类新药FGF21 的临床前研究，170万元，2019.01-2022.12，主持

1. Junjie Zhu, Zhouxiang Jin, Jie Wang, Zhaohang Wu, Tianpeng Xu, Gaozan Tong, Enzhao Shen, Junfu Fan, Chunhui Jiang, Jiaqi Wang, Xiaokun Li, Weitao Cong, Li Lin*. FGF21 ameliorates septic liver injury by restraining proinflammatory macrophages activation through the autophagy/HIF-1α axis. J Adv Res. 2024, S2090-1232 (24) 00134-6.

2. Bixin Shen, Junhui Wang, Tao He, Shihao Chen, Xue Wang, Jun Chen, Ruiqing Shi, Jing Wang, Hao Wang, Wenting Huang, Chengkun Cao, Xianxi Tan*, Jutaek Nam*, Li Lin*. Ultrasoft bioadhesive hydrogel as a versatile platform for the delivery of basic fibroblast growth factor to repair traumatic brain injury. Chem Eng J, 2024, 483: 149017. 

3. Kaiming Guo, Wenting Huang, Kun Chen, Pengkai Huang, Wenshuo Peng, Ruiqing Shi, Tao He, Mulan Zhang, Hao Wang, Jian Hu, Xinshi Wang, Yangping Shentu, Huiqin Xu, Li Lin*. Fibroblast growth factor 10 ameliorates neurodegeneration in mouse and cellular models of Alzheimer's disease via reducing tau hyperphosphorylation and neuronal apoptosis. Aging Cell. 2023, 22(9):e13937.

4. Confidence Dordoe, Wenting Huang, Canol Bwalya, Xue Wang, Bixin Shen, Hao Wang, Jing Wang, Shasha Ye, Peng Wang, Bao Xiaoyan, Xiaokun Li*, Li Lin*. The role of microglial activation on ischemic stroke: Modulation by fibroblast growth factors. Cytokine Growth Factor Rev. 2023, 74:122-133.

5. Xiaoyan Bao#, Kang Qian#, Mengjiao Xu#, Yi Chen, Hao Wang, Ting Pan, Zhengyi Wang, Ping Yao*, Li Lin*. Intestinal epithelium penetration of liraglutide via cholic acid pre-complexation and zein/rhamnolipids nanocomposite delivery. J Nanobiotechnology. 2023, 21(1):16.

6. Mengmeng Ma, Jing Wang, Hao Jiang, Qiushui Chen, Yi Xiao, Huanghao Yang*, Li Lin*. Transcranial deep-tissue phototherapy for Alzheimer's disease using low-dose X-ray-activated long-afterglow scintillators. Acta Biomater. 2023, 155:635-643.

7. Jun Chen, Zhiwei Zheng, Mingqi Li, Chengkun Cao, Xuli Zhou, Bozhen Wang, Xin Gan, Zhicheng Huang, Yugang Liu, Wenting Huang, Fei Liang, Keyang Chen, Yeli Zhao, Xue Wang, Jianzhang Wu*, Li Lin*. Design, synthesis and evaluation of monoketene compounds as novel potential Parkinson's disease agents by suppressing ER stress via AKT. Bioorg Chem. 2023, 136:106543.

8. Keyang Chen#, Wenting Huang#, Jing Wang, Huiqin Xu, Lixin Ruan, Yongang Li, Zhen Wang, Xue Wang, Li Lin*, Xiaokun Li*. Increased serum fibroblast growth factor 21 levels are associated with adverse clinical outcomes after intracerebral hemorrhage. Front Neurosci. 2023, 17:1117057.

9. Jun Chen, Katriel E Cho, Daria Skwarzynska, Shaylyn Clancy, Nicholas J Conley, Sarah M Clinton, Xiaokun Li, Li Lin*, J Julius Zhu. The Property-Based Practical Applications and Solutions of Genetically Encoded Acetylcholine and Monoamine Sensors. J Neurosci. 2021, 41(11):2318-2328.

10. Li Lin*, Smriti Gupta, W Sharon Zheng, Ke Si, J Julius Zhu. Genetically encoded sensors enable micro- and nano-scopic decoding of transmission in healthy and diseased brains. Mol Psychiatry. 2021, 26(2):443-455.

11. Bo Xing, Nancy R Mack, Kai-Ming Guo, Yu-Xiang Zhang, Billy Ramirez, Sha-Sha Yang, Li Lin*, Dong V Wang, Yan-Chun Li, Wen-Jun Gao. A Subpopulation of Prefrontal Cortical Neurons Is Required for Social Memory. Biol Psychiatry. 2021, 89(5):521-531.

12. Ruili Guo#, Xue Wang#, Yani Fang, Xiongjian Chen, Kun Chen, Wenting Huang, Jun Chen, Jian Hu, Fei Liang, Jingting Du, Confidence Dordoe, Xianxi Tian*, Li Lin*. rhFGF20 promotes angiogenesis and vascular repair following traumatic brain injury by regulating Wnt/β-catenin pathway. Biomed Pharmacother. 2021, 143:112200.

13. Dongxue Wang, Fei Liu, Liyun Zhu, Ping Lin, Fanyi Han, Xue Wang, Xianxi Tan, Li Lin*, Ye Xiong*. FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages. J Neuroinflammation. 2020, 17(1):257.

14. Xue Wang#, Liyun Zhu#, Jian Hu, Ruili Guo, Shasha Ye, Fei Liu, Dongxue Wang, Yeli Zhao, Aiping Hu, Xiaojie Wang, Kaiming Guo*, Li Lin*. FGF21 Attenuated LPS-Induced Depressive-Like Behavior via Inhibiting the Inflammatory Pathway. Front Pharmacol. 2020, 28:11:154.

15. Huan Liu#, Yeli Zhao#, Yuchi Zou, Wenting Huang, Liyun Zhu, Fei Liu, Dongxue Wang, Kaiming Guo, Jian Hu, Jun Chen, Lixia Ye, Xiaokun Li*, Li Lin*. Heparin-poloxamer hydrogel-encapsulated rhFGF21 enhances wound healing in diabetic mice. FASEB J. 2019, 33(9):9858-9870.

16. Lixia Ye, Xue Wang, Chenchen Cai, Shanshan Zeng, Junjie Bai, Kaiming Guo, Mingchu Fang, Jian Hu, Huan Liu, Liyun Zhu, Fei Liu, Dongxue Wang, Yingying Hu, Shulin Pan, Xiaokun Li, Li Lin*, Zhenlang Lin*. FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho. Exp Neurol. 2019, 317:34-50.

17. Lei Zhang, Peng Zhang, Guangfu Wang, Huaye Zhang, Yajun Zhang, Yilin Yu, Mingxu Zhang, Jian Xiao, Piero Crespo, Johannes W Hell, Li Lin*, Richard L Huganir, J Julius Zhu. Ras and Rap Signal Bidirectional Synaptic Plasticity via Distinct Subcellular Microdomains. Neuron. 2018, 98(4):783-800.e4.

18. Jun Chen, Jian Hu, Huan Liu, Ye Xiong, Yuchi Zou, Wenting Huang, Mingjie Shao, Jiamin Wu, Li Yu, Xiaojie Wang, Xue Wang*, Li Lin*. FGF21 Protects the Blood-Brain Barrier by Upregulating PPARγ via FGFR1/β-klotho after Traumatic Brain Injury. J Neurotrauma. 2018, 35(17):2091-2103.

19. Pingtao Cai, Jingjing Ye, Jingjing Zhu, Dan Liu, Daqing Chen, Xiaojie Wei, Noah R Johnson, Zhouguang Wang, Hongyu Zhang, Guodong Cao, Jian Xiao, Junming Ye, Li Lin*. Inhibition of Endoplasmic Reticulum Stress is Involved in the Neuroprotective Effect of bFGF in the 6-OHDA-Induced Parkinson's Disease Model. Aging Dis. 2016, 7(4):336-449.

（1）国家百千万人才工程

（2）国家“有突出贡献中青年专家”

（3）浙江省教学名师