周翔天


国家杰青,研究员

上海交通大学医学院科技处处长


Email:zxt@mail.eye.ac.cn


个人简介

学习经历:

1999年毕业于浙江大学医学院临床医学系,2002年毕业于温州医学院眼视光学院并获得眼科学硕士学位,2010年获得澳大利亚新南威尔士大学视光学博士学位。

工作经历

2024年1月-至今,上海交通大学医学院,科学技术处,处长

2022年01月-2023.12月,温州医科大学,科学技术处,处长

2020年01月-2021年12月,温州医科大学,国家重点实验室联合中心,主任

2020年01月-2021年12月,温州医科大学,眼视光医院集团,副总院长

2018年06月-2019年12月,温州医科大学,眼视光学院、附属眼视光医院,副院长

2016年12月-2019年01月,温州医科大学,眼视光学院、附属眼视光医院,视光学专科主任

2011年12月-至今,温州医科大学,眼视光学院、附属眼视光医院,研究员

2008年12月-2011年11月,温州医科大学,眼视光学院、附属眼视光医院,副研究员

2004年12月-2008年11月,温州医科大学,眼视光学院、附属眼视光医院,助理研究员、讲师

2002年07-2004年11,温州医科大学,眼视光学院、附属眼视光医院,研究实习员、助教

研究方向

近视发病机制研究

参与项目

主持国家杰出青年基金、国家优青、联合基金项目重点、面上项目,及浙江省重点研发计划项目等项目18项,作为骨干参加973项目、国自然基础科学中心项目、国自然重点项目等。

代表论著

1. Xiaolei Lin#; Yi Lei#; Miaozhen Pan#; Changxi Hu#; Bintao Xie#; Wenjing Wu; Jianzhong Su; Yating Li; Yuhan Tan; Xiaohuan Wei; Zhengbo Xue; Ruiyan Xu; Mengqi Di; Hanyu Deng; Shengcong Liu; Xingxing Yang; Jia Qu; Wei Chen*; Xiangtian Zhou*, Fei Zhao*. Augmentation of scleral glycolysis promotes myopia through histone lactylation. Cell Metabolism. 2024 Mar 5;36(3):511-525.e7. doi: 10.1016/j.cmet (SCI一区TOP)

2. Diferences in choroidal responses to near work between myopic children and young adults。Mengqi Liu, Yuanyuan Wang, Haoer Li, Yunpeng Zhao, Min Ma, Shihan Xu, Xiaohuan Wei, Ruiyan Xu, Ruikang Tian, Xiangtian Zhou and Hao Wu。Eye Vis (Lond). 2024 Apr 2;11(1):12.doi: 10.1186/s40662-024-00382-5.SCI一区)

3. Ziheng ShuKaijie ChenQiongsi WangHonglin WuYangfeifei ZhuRuikang TianWenjun YanQin HuangChunlan ZhangWeiwei XiongJia Qu , Xiangtian Zhou*Furong Huang*. The role of retinal dopamine D1 receptors in ocular growth and myopia development in mice. JOURNAL OF NEUROSCIENCE. 2023, JN-RM-1196-23. (SCI一区TOP)

4. Hao Wu #, Tianli Peng #, Weihe Zhou, Zihan Huang, Hongyu Li, Tengfei Wang, Jingwei Zhang, Kou Zhang, Haoer Li, Yunpeng Zhao, Jia Qu, Fan Lu, Xiangtian Zhou*, Jun Jiang*. Choroidal vasculature act as predictive biomarkers of long-term ocular elongation in myopic children treated with orthokeratology: a prospective cohort study. Eye Vis (Lond). 2023, 10(1):27. (SCI一区)

5. Shiming Jiao#, Peter Sol Reinach#, Chengjie Huang, Lan Yu, Huiman Zhuang, Hongli Ran, Fei Zhao, Nethrajeith Srinivasalu, Jia Qu*, Xiangtian Zhou*. Calcipotriol Attenuates Form Deprivation Myopia Through a Signaling Pathway Parallel to TGF-β2-Induced Increases in Collagen Expression. Invest Ophthalmol Vis Sci. 2023, 64(2):2. (SCI二区TOP)

6. Fuxin Zhao, Qihang Li, Wei Chen, He Zhu, Dengke Zhou, Peter Sol Reinach, Zhenglin Yang, Mingguang He, Anquan Xue, Deng Wu, Tianzi Liu, Qian Fu, Changqing Zeng, Jia Qu, Xiangtian Zhou*. Dysfunction of VIPR2 leads to myopia in humans and mice. J Med Genet. 2022, 59(1):88-100. (SCI一区)

7. Wenjing Wu#, Yongchao Su#, Changxi Hu, Huixin Tao, Ying Jiang, Guandong Zhu, Jiadi Zhu, Ying Zhai, Jia Qu, Xiangtian Zhou*, Fei Zhao*. Hypoxia-Induced Scleral HIF-2 alpha Upregulation Contributes to Rises in MMP-2 Expression and Myopia Development in Mice. Invest Ophthalmol Vis Sci. 2022, 63(8):2. (SCI二区TOP)

8. Furong Huang*, Ziheng Shu, Qin Huang, Kaijie Chen, Wenjun Yan, Wenjing Wu, Jinglei Yang, Qiongsi Wang, Fengjiao Wang, Chunlan Zhang, Jia Qu, Xiangtian Zhou*. Retinal Dopamine D2 Receptors Participate in the Development of Myopia in Mice. Invest Ophthalmol Vis Sci. 2022, 63(1):24. (SCI二区TOP)

9. Qian Fu , Yue Zhang , Linji ChenMengmeng DongWenyu TangSi Chen , Jia Qu, Xiangtian Zhou*Zhina Zhi*. Near work induces myopia in Guinea pigs. Exp Eye Res. 2022 Nov:224:109202. doi: 10.1016/j.exer.2022.109202.

10. Juan Lu#, Jianhong An#, Jiawei Wang, Xiaowen Cao, Yuqing Cao, Chengjie Huang, Shiming Jiao, Dongsheng Yan, Xinhua Lin*, Xiangtian Zhou*. Znhit1 Regulates p21Cip1 to Control Mouse Lens Differentiation. Invest Ophthalmol Vis Sci. 2022, 63(4):18. (SCI二区TOP)

11. Xuan Zhou, Sen Zhang, Fan Yang, Yaozhen Yang, Qin Huang, Chengjie Huang, Jia Qu, Xiangtian Zhou*. Decreased Choroidal Blood Perfusion Induces Myopia in Guinea Pigs. Invest Ophthalmol Vis Sci. 2021, 62(15):30. (SCI二区TOP)

12. Zhina Zhi, Jing Xiang, Qian Fu, Xiaomeng Pei, Dengke Zhou, Yuqing Cao, Liqin Xie, Sen Zhang, Si Chen, Jia Qu, Xiangtian Zhou*. The Role of Retinal Connexins Cx36 and Horizontal Cell Coupling in Emmetropization in Guinea Pigs. Invest Ophthalmol Vis Sci. 2021, 62(9):27. (SCI二区TOP)

13. Hao Wu, Zhu Xie, Pengqi Wang, Mengqi Liu, Yuanyuan Wang, Jiadi Zhu, Xiangqin Chen, Zhiqiang Xu, Xinjie Mao*, Xiangtian Zhou*. Differences in Retinal and Choroidal Vasculature and Perfusion Related to Axial Length in Pediatric Anisomyopes. Invest Ophthalmol Vis Sci. 2021, 62(9):40. (SCI二区TOP)

14. Miaozhen Pan, Fei Zhao, Bintao Xie, Hao Wu, Sen Zhang, Cong Ye, Zhenqi Guan, Lin Kang, Yuqing Zhang, Xuan Zhou, Yi Lei, Qi Wang, Li Wang, Fan Yang, Chenchen Zhao, Jia Qu*, Xiangtian Zhou*. Dietary ω-3 polyunsaturated fatty acids are protective for myopia. Proc Natl Acad Sci U S A. 2021, 118(43):e2104689118. (SCI一区TOP)

15. Fuxin Zhao*, Hui Zhou, Wei Chen, Chenchen Zhao, Yangyang Zheng, Yijin Tao, Miaozhen Pan, Peter S Reinach, Jiadi Zhu, Jianhong An, Runxia Lu, Jiang-Fan Chen, Huifang Tang, Changqing Zeng, Jia Qu, Xiangtian Zhou*. Declines in PDE4B activity promote myopia progression through downregulation of scleral collagen expression. Experimental Eye Research. 2021, 212:108758. (SCI二区)

16. Hao Wu, Guoyun Zhang, Meixiao Shen, Renchang Xu, Pengqi Wang, Zhenqi Guan, Zhu Xie, Zi Jin, Sisi Chen, Xinjie Mao, Jia Qu*, Xiangtian Zhou*. Assessment of Choroidal Vascularity and Choriocapillaris Blood Perfusion in Anisomyopic Adults by SS-OCT/OCTA. Invest Ophthalmol Vis Sci. 2021, 62(1):8. (SCI二区TOP)

17. Xiaowen Cao#, Jianhong An#, Yuqing Cao, Juan Lv, Jiawei Wang, Yang Ding, Xinhua Lin*, Xiangtian Zhou*. EMC3 Is Essential for Retinal Organization and Neurogenesis During Mouse Retinal Development. Invest Ophthalmol Vis Sci. 2021; 62(2):31. (SCI二区TOP)

18. Xiangtian Zhou, Cong Ye, Xiaoyan Wang, Weihe Zhou, Peter S. Reinach, Jia Qu*. Choroidal blood perfusion as a potential "rapid predictive index" for myopia development and progression. Eye Vis. 2021, 8(1):1. (SCI一区)

19. Miaozhen Pan, Zhenqi Guan, Peter S. Reinach, Lin Kang, Yuqing Cao, Dengke Zhou, Nethrajeith Srinivasalu, Fei Zhao, Jia Qu*, Xiangtian Zhou*. PPARγ gamma modulates refractive development and form deprivation myopia in Guinea pigs. Exp Eye Res. 2021, 202:108332. (SCI二区)

20. Jinglei Yang#, Li Yang #, Rongfang Chen, Yun Zhu, Siyao Wang, Xueqin Hou, Bei Wei, Qiongsi Wang, Yue Liu, Jia Qu*, Xiangtian Zhou*. A role of color vision in emmetropization in C57BL/6J mice. Sci Rep. 2020, 10(1):14895. (SCI三区)

21. Xuan Zhou#, Sen Zhang#, Guoyun Zhang, Yizhong Chen, Yi Lei, Jing Xiang, Renchang Xu, Jia Qu*, Xiangtian Zhou*. Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs. Invest Ophthalmol Vis Sci. 2020, 61(13):25. (SCI二区TOP)

22. Nethrajeith Srinivasalu, Sen Zhang, Renchang Xu, Peter S. Reinach, Yongchao Su, Yun Zhu, Jia Qu, Xiangtian Zhou*. Crosstalk between EP2 and PPAR alpha Modulates Hypoxic Signaling and Myopia Development in Guinea Pigs. Invest Ophthalmol Vis Sci. 2020, 61(8):44. (SCI二区TOP)

23. Fei Zhao#, Dake Zhang#, Qingyi Zhou, Fuxin Zhao, Mingguang He, Zhenglin Yang, Yongchao Su, Ying Zhai, Jiaofeng Yan, Guoyun Zhang, Anquan Xue, Jing Tang, Xiaotong Han, Yi Shi, Yun Zhu, Tianzi Liu, Wenjuan Zhuang, Lulin Huang, Yaqiang Hong, Deng Wu, Yingxiang Li, Qinkang Lu, Wei Chen, Shiming Jiao, Qiongsi Wang, Nethrajeith Srinivasalu, Yingying Wen, Changqing Zeng, Jia Qu, Xiangtian Zhou*. Scleral HIF-1α is a prominent regulatory candidate for genetic and environmental interactions in human myopia pathogenesis. EBioMedicine. 2020, 57:102878. (SCI一区)

24. Fei Zhao#, Hao Wu#, Peter S. Reinach, Yi Wu, Ying Zhai, Yi Lei, Li Ma, Yongchao Su, Yizhong Chen, Fen Li, Xing Liu, Nethrajeith Srinivasalu, Jia Qu, Xiangtian Zhou*. Up-Regulation of Matrix Metalloproteinase-2 by Scleral Monocyte-Derived Macrophages Contributes to Myopia Development. Am J Pathol. 2020, S0002-9440(20)30291-1. (SCI二区TOP)

25. Furong Huang, Qiongsi Wang, Tingting Yan, Jing Tang, Xueqin Hou, Ziheng Shu, Fen Wan, Yanan Yang, Jia Qu, Xiangtian Zhou*. The Role of the Dopamine D2 Receptor in Form-Deprivation Myopia in Mice: Studies With Full and Partial D2 Receptor Agonists and Knockouts. Invest Ophthalmol Vis Sci. 2020, 61(6):47. (SCI二区TOP)

26. Seema Banerjee#, Qin Wang#, Fuxin Zhao#, George Tang, Chunghim So, Dennis Tse, Chi-Ho To, Yun Feng, Xiangtian Zhou*, Feng Pan*. Increased Connexin36 Phosphorylation in AII Amacrine Cell Coupling of the Mouse Myopic Retina. Front Cell Neurosci. 2020;14:124. (SCI二区TOP)

27. Jinglei Yang #, Li Yang #, Rongfang Chen, Yun Zhu, Siyao Wang, Xueqin Hou, Bei Wei, Qiongsi Wang, Yue Liu, Jia Qu*, Xiangtian Zhou*. A role of color vision in emmetropization in C57BL/6J mice. Sci Rep. 2020; 10(1):14895. (SCI三区)

28. Zhang Sen#, Zhang Guoyun#, Zhou Xuan, Xu Renchang, Wang Siyao, Guan Zhenqi, Lu Juan, Srinivasalu Nethrajeith, Shen Meixiao, Jin Zi, Qu Jia, Zhou Xiangtian *. Changes in Choroidal Thickness and Choroidal Blood Perfusion in Guinea Pig Myopia. Invest Ophthalmol Vis Sci. 2019, 60(8):3074-3083. (SCI二区TOP)

29. Miaozhen Pan, Shiming Jiao, Peter S. Reinach, Jiaofeng Yan, Yanan Yang, Qihang Li, Nethrajeith Srinivasalu, Jia Qu, Xiangtian Zhou*. Opposing Effects of PPARa Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs. Invest Ophthalmol Vis Sci. 2018; 123, 263-270. (SCI二区TOP)

30. Liqin Jiang, Sen Zhang, Rongfang Chen, Li Ma, Xiaojun Wang, Yingying Wen, Jia Qu, Xiangtian Zhou*. Effects of the Tyrosinase-Dependent Dopaminergic System on Refractive Error Development in Guinea Pigs. Invest Ophthalmol Vis Sci. 2018; 59, 4631-4638. (SCI二区TOP)

31. Sen Zhang#, Jinglei Yang#, Peter S. Reinach, Fengjiao Wang, Lishuai Zhang, Miaomiao Fan, Huangfang Ying, Miaozhen Pan, Jia Qu, Xiangtian Zhou*. Dopamine Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs. Invest Ophthalmol Vis Sci. 2018; 59, 4441-4448. (SCI二区TOP)

32. Nethrajeith Srinivasalu#, Chanyi Lu#, Miaozhen Pan, Peter S. Reinach, Yingying Wen, Yang Hu, Jia Qu, Xiangtian Zhou*. Role of Cyclic Adenosine Monophosphate in Myopic Scleral Remodeling in Guinea Pigs: A Microarray Analysis. Invest Ophthalmol Vis Sci. 2018; 59, 4318-4325 (SCI二区TOP)

33. Hao Wu#, Wei Chen#, Fei Zhao#, Qingyi Zhou, Peter S. Reinach, Lili Deng, Li Ma, Shumeng Luo, Nethrajeith Srinivasalu, Miaozhen Pan, Yang Hu, Xiaomeng Pei, Jing Sun, Ran Ren, Yinghui Xiong, Zhonglou Zhou, Sen Zhang, Geng Tian, Jianhuo Fang, Lina Zhang, Jidong Lang, Deng Wu, Changqing Zeng*, Jia Qu*, Xiangtian Zhou*. Scleral hypoxia is a target for myopia control.Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7091-E710. (SCI一区TOP)

34. Furong Huang#, Lishuai Zhang#, Qiongsi Wang, Yanan Yang, Qihang Li, Yi Wu, Jiangfan Chen, Jia Qu, Xiangtian Zhou*. Dopamine D1 receptors contribute critically to the apomorphine-induced inhibition of form-deprivation myopia in mice. Invest Ophthalmol Vis Sci. 2018;59(6):2623-2634. (SCI二区TOP)

35. Fei Zhao#, Qingyi Zhou#, Peter S. Reinach, Jinglei Yang, Li Ma, Xiaojun Wang, Yingying Wen, Nethrajeith Srinivasalu, Jia Qu, Xiangtian Zhou*. Cause and effect relationship between changes in scleral MMP-2 expression and myopia development in mice. Am J Pathol. 2018;188(8):1754-1767. (SCI二区TOP)

36. Jinglei Yang#, Miaozhen Pan#, Peter S. Reinach, Rongfang Chen, Lan Yu, Feng Zhou, Sen Zhang, Jia Qu, Xiangtian Zhou*. Prostaglandin F2α Receptor Modulation Affects Eye Development in Guinea Pigs. Basic Clin Pharmacol Toxicol. 2018;123(3):263-270. (SCI三区)

 


个人荣誉

1、Leber遗传性视神经病研究,国家科技进步奖二等奖,2007(排名第三);

2、单纯性近视防治的临床研究及应用,国家科技进步奖,二等奖,2009(排名第四);

3、眼屈光不正个性化矫治关键技术研究与临床转化应用,浙江省科学技术进步奖,一等奖,2016(排名第三);

4、功能性眼病临床矫治关键技术研究与转化,中华医学科技奖,一等奖,2017(排名第三);

团队介绍
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联系地址:中国浙江省温州市龙湾区永中街道金石路999号

邮编:325000

邮箱:zh@ojlab.ac.cn

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