1990-1994    陕西师范大学, 学士，生物教育专业

1994-1997    陕西师范大学, 硕士，生理学专业

1997-2000    中山大学医学院, 博士，药理学专业

2000-2002    纽约州立大学布法罗分校, 生理系，博士后                     

2002-2006    马里兰大学医学院, 生理系，博士后

2007-2009    马里兰大学医学院, 生理系，助理研究员

2009-2011    马里兰大学医学院, 生理系，助理教授 

2011-2018    南伊利诺伊大学，医学院，助理教授

2017-2020    首都医科大学，人脑保护高精尖创新中心，特聘教授

2018-2021    南伊利诺伊大学，医学院，副教授（获终身教职）

2022-现在    瓯江实验室 研究员

（1）快速抗抑郁药物的作用机制和研发；（2）胶质瘤的发病机制和治疗（光遗传的方法研究多巴胺D2受体对H3 K27M-突变型弥漫性中线胶质瘤的生长调节机制）

①NARSAD Young Investigator Award (7/1/2007-6/30/2009)

Title: The role of 5-HTB receptors on excitatory synaptic transmission in temporoammonic-CA1

synapses

Role in the grant: Principal Investigator

②NIH/NIMH R01 86828 (5/15/2010-1/31/2015)

Title: Stress, Depression, Plasticity of Excitatory Transmission

Role: Principal Investigator

③NIH/NIMH R56   (9/01/2017-8/31/2020, with 1 year extension)

Title: The Essential Roles of Presynaptic NMDA Receptors in Fast-acting Antidepressant Responses of Ketamine and Its Metabolites.

Role: Principal Investigator

④Award Of National Natural Science Foundation Of China 81271488 (1/1/2013-12/31/2016)

（1）发表论文：

1. Cai X., Flores-Hernandez J., Feng J., and Yan Z. Activity-dependent bi-directional regulation of GABA_A receptor channels by 5-HT4 receptor-mediated signaling in prefrontal cortical pyramidal neurons. Journal of Physiology (London.), 540: 743-59, 2002. PMID: 11986365

2. Cai X, Gu Z., Zhong P., Ren Y., and Yan Z. Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca²⁺/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons. Journal of Biological Chemistry. 277: 36553-36562, 2002. PMID: 12149253

3. Brager DH, Cai X, and Thompson SM. Activity-dependent activation of protein kinase C mediates post-tetanic potentiation. Nature Neuroscience, 6: 551-552, 2003. PMID: 12754518

4. Cai X, Liang CW, Muralidharan S, Kao JP Y, Tang CM, and Thompson SM. Unique roles of SK and Kv4.2 potassium channels in dendritic integration. Neuron, 44: 351-364, 2004. PMID: 15473972

5. Cai X, Wei DS, Gallagher SE, Bagal A, Mei YA, Kao JP Y, Thompson SM, and Tang CM. Hyperexcitability of distal dendrites in hippocampal pyramidal cells following chronic partial deafferentation. Journal of Neuroscience, 27:59-68, 2007. PMID: 17202472

6. Misonou H, Thompson SM, Cai X. Dynamic regulation of the Kv2.1 voltage-gated potassium channel during brain ischemia through neuroglial interaction. Journal of Neuroscience, 28: 8529-38, 2008. PMID: 18716211

7. Dao DT, Mahon PB, Cai X, Kovacsics CE, Blackwell RA, Arad M, Shi J, Zandi PP, O'Donnell P; Bipolar Genome Study (BiGS) Consortium, Knowles JA, Weissman MM, Coryell W, Scheftner WA, Lawson WB, Levinson DF, Thompson SM, Potash JB, Gould TD. Mood disorder susceptibility gene CACNA1C modifies mood-related behaviors in mice and interacts with sex to influence behavior in mice and diagnosis in humans. Biol Psychiatry. 2010 Nov 1;68(9):801-10. PMID: 20723887

8. Cai X, Kallarackal AJ, Kvarta MD, Goluskin S, Gaylor K, Bailey AM, Lee HK, Huganir RL, Thompson SM. Local potentiation of excitatory synapses by serotonin and its dysregulation in rodent models of depression. Nature Neuroscience, 16:464-72, 2013. PMID: 23502536

9. Kallarackal AJ, Kvarta MD, Cammarata E, Jaberi L, Cai X, Bailey AM, Thompson SM. Chronic stress induces a selective decrease in AMPA receptor-mediated synaptic excitation at hippocampal temporoammonic-CA1 synapses. Journal of Neuroscience, 33:15669-74, 2013. PMID: 24089474

10. Thompson SM, Kallarackal AJ, Mark D,  Kvarta MD, Van Dyker AM, LeGates TA, and Cai X. An excitatory synapse hypothesis of depression. Trend in Neuroscience, 38:279-294, 2015. PMID: 25887240

11. Yang L, Xu T, Zhang K, Wei Z, Li X, Huang M, Chen S, Rose GM, and Cai X. The essential role of hippocampal alpha6 subunit-containing GABAA receptors in maternal separation stress-induced adolescent depressive behaviors. Behavioural Brain Research, (313)135-143, 2016. PMID: 27388150

12. Qi X*, Zhang K*, Xu T, Yamaki VN, Huang MF, Rose GM, and Cai X. Gender Difference in Long-term Potentiation at Temporoammonic-CA1 Synapses: Potential Implications for Memory Consolidation PLoS One, 11(11): e0165891, 2016. * equal contribution. PMID: 27806108

13. Zhang K, Xu T, Yuan ZM, Wei ZS, Yamaki VN, Huang MF, Huganir RL, and Cai X. The Essential Roles of GluR1 Phosphorylation and Presynaptic NMDA Receptor Inhibition in Fast-acting Antidepressant Responses of Ketamine. Science Signaling， 9(458): ra123, 2016. PMID: 27965425. (Cover Story)

14. Zhang K, Yamaki VN, Wei ZS, Zheng Y, and Cai X. The differential modulation on GluR1 phosphorylation and expression by ketamine and memantine. Behavioural Brain Research, 316:152-15, 2017.  PMID: 27599619

15. Wei Z, Zhang K, Zhuo Q, Xu T, Dong J, Zheng Y, Cai X. Differential mechanisms underlying antidepressant responses of ketamine and imipramine. CNS Neurol Disord Drug Targets. 2017 Apr 28. [Epub ahead of print]. PMID: 28462695

16. Yan S, Xu C, Bai S, Cheng Y, Yang M, Zhang H, He Z, Li J, Wang G, Wu J, Tong Z, Cai X*. The expression of agmatinase manipulates the affective state of rats subjected to chronic restraint stress. Neuropharmacology. 2023 May 15;229:109476.

（2）参与著书：

1. Thompson S.M., Cai X., Dinocourt C., and Nestor M. The use of brain slice cultures for the study of epilepsy. In: Models of Seizures and Epilepsy. Pikanen, Schwartzkroin, and Moshé, Eds., Elsevier. 45-58, 2006.

2. Thompson S.M., Cai X., and Dinocourt C. Mechanisms of posttraumatic epilepsy in vitro. In: Encyclopedia of Basic Epilepsy Research. Pikanen Schwartzkroin, Ed. Elsevier, 1215-1223，2009.

①2007年度-The Mr. and Mrs. Robert and Lee Peterson Southwest Florida NARSAD Young Investigator （美国脑与行为学研究会青年学者奖）

②2010年度-First prize, poster presentation of Gordon Research Conference, Neurobiology （高登会议会议报告一等奖）

诚聘博士后等科研人员，应聘条件如下：

（1）身心健康，为人踏实，热爱科研，具有良好的沟通能力和团队合作精神，有较好的英语交流和论文写作能力；

（2）获得国内外高校生物学、医学、药学等相关专业博士学位，且获学位时间一般不超过3年，年龄不超过35周岁；

（3）能独立开展科研工作，近五年内在领域内权威期刊发表过较高水平研究论文；

（4）具备分子和细胞生物学、神经科学及电生理研究经验者可优先考虑。

实验室待遇：

（1）以上岗位均依照瓯江实验室标准发放工资，享受浙江省/温州市相关人才政策，依照科研经验调整待遇 (例如温州市事业编制、安家费和购房补贴、过渡房等)。

（2）签订正规劳动合同，享受国家法定节假日、五险一金等福利。同时提供人才公寓、职工食堂、工会福利等，解决子女义务教育阶段入学或入托问题。

（3）博士后：两年总薪酬≥90万，出站后可留组工作，享受事业编制和购房优惠。

（4）欢迎相关方向或者有兴趣的本科生、研究生到实验室开展实践学习。